Drug Research
Drug Delivery

Transdermal Technologies

By Lohmann Therapy System

LTS’s research and development focuses on two new technologies to complement and expand the potential of alternative drug delivery systems. We are continually developing our TTS and OTF as well as microneedle technologies.

passive-patches-transdermal-technologies

Drug delivery via passive patches

Passive patches, which release active substance via passive diffusion, are limited to relatively small-molecule and lipophilic active substances, since only these can penetrate the skin in therapeutically relevant amounts. Consequently, active substances with larger molecules, such as peptides, proteins and vaccines, cannot be administered this way. But these new, often biotechnologically produced drugs, frequently have major potential for the therapy of diseases that until now have been inadequately treated, such as cancer.

Pain-free injections with microneedles

LTS microneedles are long enough to penetrate the outer layer of skin, but too short to irritate nerves and blood vessels. They can be used to inject active substances with larger molecules into the skin, an application that is largely pain-free. Microneedles create tiny holes in the outermost layer of skin, which significantly increases the rate at which the active substance is absorbed. LTS is currently researching a number of different microneedles made from different materials and with different gauges, designs and sizes for a wide range of applications.

Active patch for drug delivery

Active patches offer an additional way of applying transdermal therapeutic systems. This involves conducting a very low electric current through the skin, which transports the charged molecules. An iontophoresis patch consists of one unit that comprises a microprocessor and a battery, an electrode with the active substance, a counter-electrode without the active substance and the other components of the patch. This means the rate at which the active substance is absorbed can be controlled via the electric current, which itself can be precisely controlled via the microprocessor.

Iontophoresis enables substances to be absorbed transdermally that are not suitable for passive systems as a result of their intrinsic characteristics, including charged molecules. LTS has managed to achieve good storage stability by employing innovative drug delivery forms and the very latest concepts. This technology offers a wide spectrum of potential applications.

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