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Drug Delivery White Papers

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16-30 of 37 results
Dye-free quantification of Oragene®/saliva DNA extracts using the Trinean DropSense96® Droplet Reader and cDrop™ Spectral Analysis Software
| By Trinean
Saliva samples collected with Oragene® self-collection kits from DNA Genotek offer a non-invasive and proven method for accessing high quality and quantity DNA for genomic testing and analysis. Proper quantification of the extracted DNA is a critical step for most downstream applications. Trinean has developed a specific quantification protocol for DNA from Oragene/saliva samples using the DropSense96® droplet reader and the cDrop™ spectral decomposition software. A comparative analysis using a PicoGreen® fluorescent quantification assay shows a comparable specificity for dsDNA quantification. Since the read-out of 96 samples with the DropSense96 is performed in 5 minutes without any prior mixing or incubation, this technology is a viable alternative to fluorescent quantification assays.
Drug Research > Drug Delivery > White Papers
1.17 Maxwell®16 Blood purification Kit App and Maxwell®16 LEV Blood DNA Kit App
| By Trinean
A spectral content profiling application on the cDrop™ software is available for quantification and contamination analysis of DNA isolations from blood using the Maxwell® 16 Blood DNA purification Kit and The Maxwell®16 LEV Blood DNA Kit. In this note we describe how to use this application and how to export and interpret the results.
Drug Research > Drug Delivery > White Papers
1.7 Quantifying Amplicons in Non-Purified PCR Reactions: Direct Assessment of Product Yield
| By Trinean
The polymerase chain reaction (PCR) is a fundamental tool in molecular biology and clinical testing. Most genetic tests rely upon the power of PCR to enrich specific target-sequences prior to analysis. Analytical methods like sequencing are relatively expensive and labs want to minimize the resources spent on samples that don't meet the requirements of concentration and quality to deliver a reliable result.
Drug Research > Drug Delivery > White Papers
1.19 Qiagen® EZ1 Tissue DNA app
| By Trinean
A spectral content profiling application on the cDrop™ software is available for quantification and contamination analysis of DNA isolations from cells using the Qiagen® EZ1 Tissue DNA kit. In this note we describe how to use this application and how to export and interpret the results.
Drug Research > Drug Delivery > White Papers
1.10 cDrop Protocol for TRIzol RNA Extract Quantification and Content QC
| By Trinean
This cDrop protocol is developed for specific RNA quantification of extracts from a variety of sample origins (human, animal, plant) using extraction kits based on the one-step extraction method using a guanidinium thiocyanate-phenol- chloroform reagent-mix developed by Chomczynski (1). Commercial available variants include the TRIzol® kit (Invitrogen), TRI Reagent® (MRC), RNAzolTM (MRC) and RNA STAT-60TM (Tel-Test).
Drug Research > Drug Delivery > White Papers
All-Purpose Protein Sample QC Using a Novel Micro-Volume Platform with Spectral Content Profiling Software
| By Trinean
Accurate total protein quantitation of purified proteins, cell lysates, affinity-column fractions or other complex protein samples is crucial for robust biochemical testing during biopharmaceutical development as well as production. As the presence of chemicals doesn't allow simple A280 protein quantification, more labor-intensive alternatives for quantification are used. Examples are the colorimetric Bradford or BCA assay, which negate to a large extent the presence of contaminants but require multiple steps and show variation depending on the sample composition and time point of measuring within the ongoing reaction.
Drug Research > Drug Delivery > White Papers
Precise Nucleic Acid Quantification Using Lab-on-a-chip Spectroscopy and the cDrop Quantification Algorithm
| By Trinean
Precise quantification and quality control of isolated genomic DNA is critical for the success of downstream applications such as next-generation sequencing. Traditionally, two quantification methods have been used routinely: (1) UV/Vis spectroscopy and (2) fluorescence-based assays (i.e. PicoGreen) that utilize DNA intercalating agents.
Drug Research > Drug Delivery > White Papers
Sample Processing for the UK Biobank Genotyping Project
| By Trinean
A project was initiated in 2013 to perform SNP genotyping on all UK Biobank participants. The aim of the project (which was to be completed within an 18-24 month timeframe) was to generate high quality genotype data and to make these data available for researchers, via the UK Biobank Showcase system. This poster describes the sample processing workflow, presents a comparison between the two quantification methods used in the project (Trinean DropSense® 96 and PicoGreen) and provides a summary of the genotyping metrics for the (approx.) first 180,000 samples analysed.
Drug Research > Drug Delivery > White Papers
Droplet UV/VIS Quantification of Native Proteins in Biopharmaceutical Processing
| By Trinean
Biopharmaceuticals are mainly produced by microbial fermentation or in animal cell cultures. As a consequence, a cascade of procedures including purification and characterization are required throughout the processing chain to obtain the protein at the desired level of purity and potency. Within these processes, quantification of the protein of interest is mandatory at critical steps to maintain confidence in the processing results and fidelity in the end product.
Drug Research > Drug Delivery > White Papers
Designing Wellness for Fun and Satisfaction: Gummies - Based Nutrition
| By Softigel pbr
The gummy delivery form for vitamins, minerals and supplements is the single-largest source of growth among the supplements category. Vitamin users report preference for gummy/soft chewable products because these offer not only pleasure and a fun experience, but efficacy and convenience. The selection of materials during the design process of the formula is critical for the final product in order to meet the expectations of the consumers, which is to find a healthy product that will give them a delicious reward as well. Based on the design and development process, this paper reviews review in detail the stage of selection of materials and validation as a critical phase to obtain a product that represents quality and stability as well as the specific requirements of the costumers and the consumers.
Drug Research > Drug Delivery > White Papers
A High Quality Formulation Development and Manufacturing Company
| By Alpex Pharma
Our predominant focus is the development of solid dosage forms to deliver drugs directly into the oral cavity in order to potentially improve both the bioavailablity of the drug as well as patient compliance and convenience to it. Alpex Pharma has 28 years of cGMP manufacturing experience and formulation development.
Drug Research > Drug Delivery > White Papers
Signed by Syncom - Designing Chemistry in 25 Milestones
| By Syncom BV pbr
There are so many reasons to be proud of this company. In the first 25 years of Syncoms’ existence, we have truly made a contribution to science, the pharmaceutical industry, the health of many people across all continents, to the economy of our city (Groningen), as well as to the careers and lives of employees and former employees.
Drug Research > Drug Delivery > White Papers
Syncom Catalogue
| By Syncom BV pbr
Click here to download our catalogue of products.
Drug Research > Drug Delivery > White Papers
Softigel Technologies Brochure
| By Softigel pbr
From selecting the best gelatin source, throughout the soft gelatin capsule development, manufacturing, labeling and packaging process, until delivering a final product to your warehouse with supporting marketing strategies, SoftiGel is vertically integrated to fulfill your needs and deliver the best drug to any marketplace in the world.
Drug Research > Drug Delivery > White Papers
SoftiGel Product Catalogue
| By Softigel pbr
Download our whitepaper for details of our pharmaceutical capsules and products.
Drug Research > Drug Delivery > White Papers
16-30 of 37 results